The Missing Link between Candida albicans Hyphal Morphogenesis and Host Cell Damage

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The Missing Link between Candida albicans Hyphal Morphogenesis and Host Cell Damage

1 Aberdeen Fungal Group, MRC Centre for Medical Mycology, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Institute of Medical Sciences, Aberdeen, United Kingdom, 2 Mucosal & Salivary Biology Division, Dental Institute, King’s College London, United Kingdom, 3 Department of Microbial Pathogenicity Mechanisms, Hans Knoell Institute, and Friedrich Schiller University, ...

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RAM (regulation of Ace2p transcription factor and polarized morphogenesis) is a conserved signaling network that regulates polarized morphogenesis in yeast, worms, flies, and humans. To investigate the role of the RAM network in cell polarity and hyphal morphogenesis of Candida albicans, each of the C. albicans RAM genes (CaCBK1, CaMOB2, CaKIC1, CaPAG1, CaHYM1, and CaSOG2) was deleted. All C. a...

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Candida albicans is termed a dimorphic fungus because it proliferates in either a yeast form or a hyphal form. The switch between these forms is the result of a complex interplay of external and internal factors and is coordinated in part by polarity-regulating proteins that are conserved among eukaryotic cells. However, yeast and hyphal cells are not the only morphological states of C. albican...

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ژورنال

عنوان ژورنال: PLOS Pathogens

سال: 2016

ISSN: 1553-7374

DOI: 10.1371/journal.ppat.1005867